A Step towards Resolving the Mystery of HPV Vaccination: Breakthrough of Cervical Cancer

HPVs (Human Papilloma virus) are associated with a variety of clinical conditions that ranges from less harmful lesions to life threatening cancer. During the onset of 19th century, HPV association with human cancers has been found with major links to genital warts and cervical cancers [1]. With recent advances in HPV vaccine, the possibility of preventing the second most common cancer among the women is promising. But as these vaccines are prophylactic vaccines there is a dynamic need for the development of therapeutic vaccine. In this review, we would discuss about HPV and Cervical cancer, immunological aspects of HPV infection, current vaccines and vaccine case studies, recent strategies employed for the development of therapeutic vaccines with emphasis on second generation vaccine and its future prospects.